The Wiiimote and Nunchuk combo needs a little tweaking (maybe make the wiimote more like a nunchuk for ergonomics, give it an analog stick for coarse camera movement) but it was the most comfortable controller ever since I could place my hands in different positions relative to one another.
For C&C fans, Tempest Rising is C&C in all but name. The most recent playtest felt like a hybrid of Tiberian Sun and Tiberium Wars. It’s not out yet, but I’m very excited about it.