“I would rather have questions that can’t be answered than answers that can’t be questioned.” - Rich Feynman
The only real option worthwhile is to get nerdy and play the same game. Change up how and what you connect online as well as running security and privacy based open source firmware + software on your devices. Aside from that, protesting would be another option with some teeth too!
I have yet to see it, but in addition to the lackluster reddit thread, here are the IMDB reviews: https://imdb.com/title/tt16283824/reviews
While IMDB has rated a number of films/shows I love well lower than I feel they should be, all in all the scores tend to be a pretty good indicator. They rated it 7/10 with some folks ranting and raving about it, while others say the show tried to fit too much into it. Hope this is at least somewhat helpful.
In Fedora? I’ve had one or two issues with the updater if I postponed the updates for a while, yet sudo dnf update always fixed the issue. I feel like thats step one for terminal use really. It’s also nice when it’s done this way you typically don’t need to reboot, unless it’s kernel or driver updates.
I feel like Mint is the move if you never want to utilize the terminal. But while it can be intimidating initially, after using it, you’ll grow to love it. Truly makes life way easier. I learned by first finding threads on my issues to copy and paste commands. After doing that enough you’ll gain an understanding of the main commands pretty quick. Fedora is a great starter in my mind, as you can do everything through the GUI when first starting, but unlike Mint, you can still get nerdy with the terminal when you feel up to it. Using a VM is a solid option to learn the terminal without any risk, worst case just delete the VM and make another. But you’d have to mess up pretty thoroughly to need to do that in my experience. Fedora, or Nobara which is a gaming and media centric fork of Fedora, are amazing due to the ability to run great out of the box plus being able to dial in anything you want to alter for your needs down the road. Fedora’s Software center allows you to add flatpak and snap packages, so it’ll all be in one place. Fedora 40 makes NVIDIA drivers pretty easy to deal with too. But this is just my two cents, I’m curious to see what others recommend for you.
Good on you for being so knowledgeable about the disorder. But 100% ask your doc, being real with my doc has taken our appointments to the next level. The genome is only half of the IgE allergy response, other half is the environment you were raised in as you can build tolerance of it. A high genetic aspect can be countered by a “low hygienic” environment according to research.
Well, in digging into some research papers, I found “mast cell activation can be caused by both IgE-mediated and non–IgE-mediated triggers”.
This is because there can be a mast cell mutation (KIT) which then doesn’t require IgE for activation. You have MMAS and not Mastocytosis, right? The mutation seems to be associated with Mastocytosis based on my understanding from the paper.
Since mast cells aren’t privileged, they’re restricted from entering sites like the brain and spinal cord. So, if they’re in the spinal cord, you almost certainly have bigger problems than mast cell activation I’d think, as the barrier isn’t doing it’s job.
In case you’re interested, here’s the paper on mast cell disorders: https://www.jacionline.org/article/S0091-6749(17)31025-4/fulltext
Here’s one on the brain and spinal cord: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481533/
The BIGGEST issue with our understanding of the immune system today is that ALL testing is done on mice. The human body on a chip technology along with the digitization of the immune system together will be a monumental step. Thankfully, it’s literally something we’ll have in the near future. Once that’s available, we’ll have human specific data plus an onslaught of constant information, which we need to help folks with all of the immune system disorders. I’m an autoimmune patient and losing my friends and family to this uncertainty has led me into the field to try and help improve our understanding. There’s legit more we don’t know than we do know about the human immune system right now.
Using cash to buy a prepaid card is always a decent option. Makes it very difficult to associate the payment with the buyer. As far as a MySudo alternative, keep an eye on JMP.chat! They do work in the EU now, but they only provide US numbers. However, they are actively working on being able to provide EU numbers at least.
While there’s no free floating IgE in your system, to degranulate mast cells need IgE bound to their surface. Thats the activation aspect. Since you need mast cells, it’s not exactly something you can turn off. Glad you know the triggers at least, gives you the opportunity to make moves accordingly!
Here’s a great image of degranulation:
You need two IgE’s to cross-link the same antigen as well, like what is shown above.
Yep! Mast cells are activated when IgE antibodies bind to a mast cell receptor. When IgE then binds to the one object it was designed to find, you get mast cell degranulation. This releases histamines along with a few other chemicals. Degranulation is our immune defense against parasites, so you got a head start for parasite defense for sure! But desensitization can be achieved, which makes IgG antibodies bind to the foreign object before IgE has the chance. I’d think this could be a possible treatment for the syndrome.
Do you also have asthma? The same IgE’s also bind to eosinophil’s. Mast cell degranulation in the lungs leads to acute asthma, whereas when eosinophil’s join the party it causes airway remodeling, aka chronic asthma.
It’s no picnic, parasites are burly! The Th2 adaptive immune response for worms, our only parasite response, is only good with small initial infections. But since the side effects are relatively mild considering all parasites, it’s not a big area of focus.
Fun fact: The same response for parasites causes allergies. You can never be allergic when it’s your first exposure either. But a less hygenic environment as a kid greatly redices the risk of developing allergies.
Of course!
This ones about the evolutionary benefits: The origin of risk aversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273387/
Here’s one on fatal motorcycle accidents: Increased risk of traffic accidents in subjects with latent toxoplasmosis - a retrospective case-control study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117239/
For good measure, here’s one on business owners and the parasite: Risky business - linking Toxoplasma gondii infection and entrepreneurship behaviours across individuals and countries https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083268/
Toxoplasmosis is very intriguing, it has actually evolved alongside cats and humans for ages. While anyone with an immunodeficiency is at higher risk of severe side effects, like with any pathogen, it’s also associated with taking bigger risk. This is why a ton of motorcyclists and casino regulars test positive for the parasite. But when we were hunter gatherers, the infection was associated with bringing home bigger kills, which helped the entire tribe. Due to this, toxoplasmosis infections had sizable benefits and those with the infection often had positions of power in tribes!
The researchers believe it affects all VPN applications when they’re connected to a hostile network and that there are no ways to prevent such attacks except when the user’s VPN runs on Linux or Android.
Once again, Linux with a win!
Aegis is my absolute favorite for 2FA’s, give it a try for sure. Pretty sure it’s only available on Android unfortunately though.
So Meta, Twitter, Snapchat and all the others who’ve redefined what data collection looks like and keep folks self centered is fine? The only reason the US is throwing this fit is because they can’t access the collected data like they can with US based data brokers, I mean social media. The key aspect of this ban revolves around freedom of speach more than anything else.
If you’re talking OpenWRT, then I totally agree. But something like Asus Merlin is a relatively easy change and still provides additional protection. While part of the Asus code is closed-source, most is open-sourced and Asus has implemented improvements developed by the Merlin team. This shows Merlin knows what they’re doing and are trustworthy too.
Running as much open-sourced privacy oriented software as possible. This includes on computers, routers, and phones. While this is 100% a marathon, not just a quick change, it’s well worth the time. Utilizing an encrypted DNS would be another solid move. NextDNS is a fantastic choice as it has a free option which still provides granular control of what is filtered online. A trusted VPN mixing your internet traffic with others is great, but like you said, it’s not a magic bullet whatsoever.
In the big picture, it’s due to the microscopic world having massive implications across life. I’ve also lost friends and family to autoimmune disorders and cancer, so my long term goal is to improve our understanding in the field. Immunology is super fascinating, but there’s more we don’t know than we know about the immune system. We don’t even understand how fever works or Tylenol from start to finish for example!
What makes you stoked about physics?
Mines a toss up between microbiology and immunology, but I also totally get your favorite as it’s the basis for all sciences!
The facts are it’s an oligopoly which is rapidly moving towards pairing this with totalitarianism. Propaganda is so pronounced today that finding actual news is a chore, and if shared it’s labeled as “fake news”. A study was recently published demonstrating political moves are made without any care for how it impacts the masses. It’s tough to see the decline happen in real time while most deny it’s occurrence. Most are too focused on owning others in the working class with alternative ideals.
But in the U.S., the natural beauty is phenomenal. Yet it’s being traded to allow conglomerates to squeeze more profit out of dwindling resources. If something doesn’t change the course soon, this answer potentially could land me in prison in the near future. Which is counter to what the country was supposedly established to prevent. It’s rough in many aspects, yet not entirely hopeless, at least as of this moment.