Following on from their breakthrough human trial that successfully reprogrammed the immune system to overpower glioblastoma, an aggressive brain tumor, the same scientists have now further developed the mRNA vaccine to fight not one but any cancer. It has the potential to do away with chemotherapy,…
  • SabinStargem@lemmy.todayEnglish
    86·
    20 days ago

    Hopefully, the researchers will be fully employed by the EU. I wouldn’t trust the US to not fuck up this miracle.

  • Grandwolf319@sh.itjust.worksEnglish
    43·
    20 days ago

    While the formulation isn’t unlike the Covid-19 vaccine, which uses lipid nanoparticles to deliver the genetic instructions to the body, it is still somewhat different. Instead of the drug encoding a virus protein, it sends a message to the immune system to rally the troops. It essentially tells the body to produce certain proteins that stimulate the immune system – including a protein within cancer cells known as PD-L1 (Programmed Death-Ligand 1), which makes tumors become more visible to immune cells.

    TLDR: they are finding that it’s more effective to make cancer more visible and have the body’s immune system do its thing.

  • Lovable Sidekick@lemmy.worldEnglish
    42·
    19 days ago

    It has the potential to do away with chemotherapy, surgery and radiation treatment.

    I read that as: Will never reach the market because it threatens a multibillion dollar industry.

    But srsly, glioblastoma is a really nasty motherfucker with a very low patient survival rate, so if they’ve really managed to cure it that’s a huge milestone.

    • ColeSloth@discuss.tchncs.deEnglish
      141·
      20 days ago

      But this was based on their treatment of glioblastoma working in humans, and is a modified version of that one.

  • iturnedintoanewt@lemmy.worldEnglish
    382·
    19 days ago

    Previous research has focused more on homing in on a target or tailoring a vaccine specific to a patient’s own cancer profile.

    “This study suggests a third emerging paradigm,” said study co-author Duane Mitchell, MD. “What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. And so this has significant potential to be broadly used across cancer patients – even possibly leading us to an off-the-shelf cancer vaccine.”

    So… Kinda triggering your own auto-inmune response. But I’d be wary of trouble with overtly aggressive auto-inmune responses, as we already have quite a few diseases coming from these, as well.

    • eletes@sh.itjust.worksEnglish
      14·
      19 days ago

      I guess if I was gonna die and absolutely wanted more time I would make the trade off for living with lupus

      • Jännät@sopuli.xyzEnglish
        8·
        19 days ago

        As someone with an autoimmune disorder, I’m honestly not all that sold on whether that’s a good tradeoff.

        Yay, you’re not acutely dying of cancer, but now your body is attacking your internal organs and depending on how shitty your luck is, you can eg. look forward to liver and/or kidney transplants (possibly more than once, too)

      • ameancow@lemmy.worldEnglish
        8·
        19 days ago

        Because Hollywood is so insanely bad at portraying science even remotely accurately, literally everything sounds like the plot to a zombie movie.

        I’m not even kidding, I’m not in the biotech field and even I feel my eye twitch every time I see a movie with zombified lab animals smacking into the bars of their cages as the plucky heroes try to unravel what vile sins against nature those evil researchers uncovered in their hubris.

    • Taleya@aussie.zoneEnglish
      1·
      19 days ago

      Yeah i’ve had RA since i was 12, that explaination of function just made my brain screech

  • vga@sopuli.xyzEnglish
    24·
    19 days ago

    I’m gonna be watching with popcorn when anti-vaxxers get cancer and definitely 100% will take this vaccine.

    I mean, if it’s true and not just shit science reporting that I assume it is.

  • BarneyPiccolo@lemmy.todayEnglish
    18·
    19 days ago

    Too bad we got a Sociopathic Oligarchs as HSS, who thinks mRNA vaccines should be banned. Cancer is better than…well, whatever is wrong with mRNA vaccines.