In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.
Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649
As a 50+ year old mechanic, this can’t come soon enough.
Wow yes. So many older and retired workers from the skilled trades could benefit from this.
It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.
Arthritis is not limited to trade workers, anyone can have it.
And it isn’t the only health issue physical work can cause.
Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.
I don’t think arthritis is the win you think it is.
Honestly I’d take that over this arthritis
It’s in my mouse clicker finger and starting to make video game controllers uncomfortable. Make it stop!
Uhg. Sad reality.
Or move outside the US
Or win the lottery.
Spoiler alert: you can’t afford it.
also cancer :)
Any of the “regrows damage” side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don’t want to play chicken with C
Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.
Not in this case.
“Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer.”
The news article, as well as the published work, state that:
Cartilage regeneration appears to occur through gene expression changes in pre-existing chondrocytes, rather than stem or progenitor cell proliferation.
Long-term side effects will need to researched of course and there might still be stem cells involved in the process, however that doesn’t seem to be the case according to what we know as of now.
I will gladly throw it on top of my monstrous pile of promising-looking research in hopes that it becomes a successful procedure.
Speak for the Americans. The rest of us have no trouble doing so
Thank you for doing useful work
The rich are going to live well
So are non Americans
Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.
Most definitely. I’m almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.
If this gets proven to work in vivo in humans I’m certain we’ll see the same no matter side effects.
I’ve also heard the peptide hype. I’m curious, as an aging athletic person - but also I don’t want to roll the dice with cancer
“I just popped a kneecap, it shot clean off and broke a mirror. Pill me babay!”
Between this and growing new teeth, things are looking a lot more cyberpunk than before.
In that only the upper wealthy class will be able to afford it?
So…there’s a chance I can back into martial arts? Bring it.
Martial arts should probably be approached from the front, but you do you, boo.
What the fuck? All we ever needed was a pill? Is everybody stupid?
Damn mice’s at this point they will reach immortality first. Then again thankful for that lol.
They’ll deserve it, the shit we’ve put them through.
I feel there’s very little the rest of the world should emulate of modern Russia, but this is one example that I would like to see mimicry of: https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse
I wonder if you’d have to stay off of those joints for months to allow the regrowth to occur properly.
The question is “Does 15-PGDH do something beneficial and would suppressing it have serious side effects?”
I found this:
15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.
So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.
reproductive urge, you mean.
Plenty of women with the equipment and no intention of using it.
Well, that’s part of what you’d have to consider. The reply didn’t state it would be contraindicated in reproductive age, just that it shouldn’t be applied without consideration.
